Organic DNA detection work highlighted in Nature Materials

Single DNA mismatch sensor work on Nature Materials Research Highlight

Researchers Organic thin-film transistors (OTFTs) have been suggested as low-cost biochemical sensors, owing to easy processing and chemical tunability. So far, however, the in situ recognition of oligonucleotides has remained an outstanding challenge, not least because of the sensitivity of many organic semiconductors to water. Hadayat Ullah Khan and colleagues have now developed an OTFT-based sensor that detects single-stranded DNA (ssDNA) with high selectivity and sensitivity. The researchers report measurements at concentrations down to 1 nM, as well as the detection of mismatches as small as a single base-pair. Their microfluidic device is based on a bottom-gate transistor that is covered with a 5-nm-thin film of a polymeric dielectric...

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